Therefore, the current study used stringently defined ER α-negative tumours and so was enriched for a generally more aggressive group of breast tumours.
Our work here presents the first study that stringently demonstrates the plasticity between multiple NSCLA non-CS/PC and CS/PC subpopulations, and supports a model describing the stochastic transition of breast cancer cells.
There is debate about whether the wide opened to the cytoplasm conformations observed in some studies are stringently required for transport activity.
Studies of stringently defined models of mouse reprogramming have shown that cell-type-of-origin-specific differences in gene expression and differentiation potential exist in early passage iPSCs, leading to the hypothesis that an epigenetic memory of previous fate persists in these cells [ 98, 99].
15, 16 In this study, we use stringently filtered microarray data to identify and characterize transcriptional changes that are associated with kidney transplantation and acute allograft rejection.
Although there are multiple causes for the 'reproducibility crisis', deliberately including genetic variability may be a simple solution for increasing the reproducibility of ecological studies performed under stringently controlled environmental conditions.
This pragmatic approach captures the exact context in which a diagnostic biomarker would be used by clinicians (i.e., patients with a clinical suspicion of bacterial infection), one that may lead to more generalizable results as compared with a study based on more stringently selected patients.
Stringently controlled studies are required, ideally against direct indicators of the patient's immune status.
Our study clearly demonstrates that a stringently selected shRNA-library is well suited for the unbiased identification of novel potent and non-toxic shRNAs in addition to those predicted by commonly used public algorithms.
First, we confirmed the influence of Toxoplasma infection in BD by analysing a much larger sample than in a previous study (Table 1) and also by stringently selecting those born in France for sample homogeneity (Hamdani et al. 2013).
