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Despite inevitable flaws (such as small individual study sizes, publication bias, etc).
However, the quality of the evidence was judged as 'low' GRADE due to the methodological limitations of the included studies, and overall small study sizes.
How many more variants can we expect to discover and what study sizes are needed?
Fifth, potential bias has several considerations: included studies were non-randomized researches; the study sizes were relatively small; the relatively high heterogeneity among studies; some subgroups included only a few studies; chance related bias.
The other problem with these previous studies is that a limited number of samples were available for analysis and consequently study sizes fell below the threshold for reliable statistical analysis.
Interpretation of CNV association findings must take into account the effects of filtering and combining CNV calls when based on early genome-wide genotyping platforms and modest study sizes.
In sum, these factors will lead to increased sample return rates which will increase study sizes and ultimately enhance the ability for geneticists to detect novel genetic loci underlying disease and behavioral traits in a GWAS framework.
Although effective risk reduction counseling and condom promotion has positive public health implications, substantially larger study sizes may be required to achieve adequate numbers of HIV endpoints in a clinical trial.
Study sizes ranged from 81too 250.
Study sizes show notable variation across medical specialties.
Study sizes were generally small (median sample size = 30).
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