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More recently, the study resolving the crystal structure of the S1R reported the protein to possess a single TM domain with a short N-terminus facing the ER lumen, while most of the protein bulk was located on the cytosolic side of the ER membrane (Schmidt et al., 2016) (Fig. 1A).
Both authors extracted the information from each study, resolving any disagreements by discussion.
It was considered important to perform another quality study resolving these issues with a three-arm design, including a higher dose within Baxter's recommended range and with long-term follow-up.
The only previous study resolving relationships among basal lineages was based on plastid ndhF sequences [ 42] and resolved Calostemmateae and Haemantheae as sisters and tribe Cyrtantheae as sister to these.
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