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It is conceivable that this putative sensor is activated upon release from the ECM depot, and, as proposed in our study, regulates MMP expression via the β-catenin pathway.
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Correlated genes discovered in this study regulate nervous system development, and are associated with various types of cancer and neurological disorders.
This is perhaps best illustrated by observations that although p21 is a very well-described p53 target it is, as also demonstrated in the current study, regulated by p53-independent mechanisms.
The aim of this study is to examine whether aspirin, which has been reported as an effective drug improving bone mineral density in human epidemiology studies, regulates the balance between bone resorption and bone formation at stem cell levels.
Generally, these results were in agreement with the functional analysis of the studied regulated genes, which suggested that these miRNAs may also be the causes of these abnormalities.
To further study miRNAs regulated by TDP-43, we examined which miRNAs interact with TDP-43.
Moreover, the intrinsic optical [19, 20], magnetic [21, 22] and biological properties of nanomaterials offer remarkable opportunities to study and regulate complex biological processes for biomedical applications in an unprecedented manner [23 25].
No specific forms of nitrogen measured in this study are regulated, nor are TOC.
Additional polymorphisms observed in this study may regulate expression levels of transporters and could provide an explanation for some variability observed in drug disposition.
Pathway and network analyses were performed to study significantly regulated genes.
At least eight genes induced by HMF in this study were regulated by both Pdr1p and Pdr3p.
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