At any rate, the addition of oxaliplatin to vinorelbine seems to bring no advantage, thus discouraging further studies in this doublet.
As a follow-up to our recent study on extant silicoflagellate doublets, we present a compilation of data on the fossil record of silicoflagellate double skeletons, with particular focus on the Cretaceous and Paleogene.
However, recent studies have explored alternative schedules of this doublet, providing increasing amounts of data regarding dose-dense chemotherapy.
This doublet of doublets (JH P=40.4 Hz, JH P=6.7 Hz) collapses to a singlet on proton decoupling.
Triple-negative tumors showed particular susceptibility to this doublet.
This doublet provides a potentially active non-platinum containing doublet for the treatment of patients with advanced SCLC and NSCLC.
However, this doublet was replaced in stage IV patients by more efficient new-generation cisplatin-based doublets (including vinorelbine, taxanes, gemcitabine and more recently pemetrexed).
In this study, however, the doublets were pooled from diverse pathways; namely, not limited to those of the gene pairs belonging to the same pathways.
The concept of this SWOG study which involved a doublet followed by taxane, is similar to that of the present study.
In a study on 344 sHSPs, Fu et al. [36] showed that the P-G doublet is highly conserved in most of the non-animal sHSPs.
