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Furthermore, immunohistochemical study of the lung tumor was performed with multiplex antibody reagent (Pathology Institute corporation, Toyama, Japan) containing napsin A (clone: TMU-Ad02) and TTF-1 (clone: SPT24).
Finally, there are several available samples that can be used in the bioinformatics study of the lung, such as exhaled breath gas, blood, lung tissue, pleural effusion and BALF, which may largely facilitate the biomarker research.
To date, there is only one study of the lung LB proteome that identified 44 proteins in isolated rat lung LBs [15].
In the largest study of the lung adenocarcinoma genome, never smoker status was associated, although not significantly, with amplification of 7p-q and 16p and deletion of 10q and 15q [215q
Sampling of pulmonary oedema fluid from the distal air spaces is an important procedure that allows the study of the lung inflammatory response.
The study of the lung epithelial response to airway injury has shown compelling evidence for the role of stem cells as a component of airway repair [10].
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The anterior-posterior radiographic view is undoubtedly less accurate for the study of the lungs.
In a small post-mortem study of the lungs of patients who had died with 'severe respiratory failure', Zapol et al. demonstrated that there is increasing destruction of the capillary bed as ARDS progresses, which may contribute to elevations in the PVR of the same patients measured ante-mortem [54].
The oropharyngeal sample as a control for microbiologic studies of the lung is rooted in the belief that the lungs should be sterile; thus, the purpose of the oropharyngeal sample is to rule out contamination.
Most studies of the lung microbiota have been cross-sectional, observational and descriptive in nature [ 18].
These specific regions were selected based on previous studies of the lung cancer genome [ 25, 26] and through our global mapping with CNAG.
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