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Cells grown in vitro are more accessible for study of the developmental processes associated with xylogenesis.
For example, a study of the developmental origin of aortic arch asymmetry involves a mixture of reductionist and non-reductionist representations according to the criterion of temporality (Yashiro et al. 2007).
The study of the developmental basis for phenotypic variability addresses a higher level of abstraction in that it deals with the tendency of developmental systems to change, amplify, or reduce the expression of genetic variation at the phenotypic level.
Here, we present a detailed study of the developmental expression profiles of three BMP ligands (Bmp2, Bmp4, Bmp7) and three BMP receptors (Bmpr1a, Bmpr1b, and BmprII), as well as their molecular antagonist (noggin), in the early embryo during the initial steps of murine organogenesis.
These observations may lay a solid foundation for further study of the developmental delay or abnormalities in various brain disorders.
The results of our study of the developmental abnormalities in these cohorts were previously reported [ 42].
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Surprisingly, this important information is currently lacking, despite hundreds of studies on the developmental functions of the Ras-MAPK pathway.
DNA methylation, a key epigenetic mechanism, is a clear focus of studies on the developmental origins of health and disease.
The majority of the studies on the developmental origin of adult adverse outcomes use laboratory animals (rats and mice).
However, with increasing knowledge of transitional fossil forms, increasing consensus over their relationships, and with progress in studies of the developmental processes underlying the formation of digits, it becomes increasingly difficult to define what constitutes either a digit or indeed a tetrapod.
Early studies of the developmental hourglass effect mostly analyzed morphological and phenotypic similarities across species.
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