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We proceeded to compare fibril-derived protofibrils (further termed 'backward' protofibrils) with the extensively studied soluble protofibrils formed during the aggregation process of fresh Aβ (and further termed 'forward' protofibrils).
Thus, the current study intends to demonstrate that the inhibition of the aggregation process of β-amyloid in vitro by applying weak microwave fields (0.1 W) is possible in the presence of AuNP.
The generic nature of the aggregation process has enabled extensive studies of the transition between soluble precursor states and insoluble amyloid fibrils in vitro [108].
Furthermore, peptide dimerization was the primary step of the aggregation process.
We have also sought to incorporate details of the aggregation process.
This may be explained by increased aggregation of tau at acidic pH and may reflect the kinetics of the aggregation process.
Since the aggregation process was studied out of equilibrium, we ran for each IPC type 10 MC runs in parallel starting from different initial conditions.
Taken together, these results suggest that DJ-1 may prevent aSyn aggregation by interfering with the initial steps in the aggregation process of di- or oligomerization.
By contrast, aggregation inhibitors such as MB interfere with the aggregation process but do not affect de novo synthesis of pro-aggregant toxic Tau.
This study deals with the analysis of the aggregation processes of a colloidal silica suspension destabilized by addition of salt under different flows: a turbulent flow performed in a stirred tank, a pure shear flow created thanks to a Couette geometry and an extensional flow obtained in a four-roll mill (Taylor cell).
The need for competitive studies involving other wine components on the aggregation processes is identified.
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