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One way to explore the species pangenome is to conduct a comparative genomic study of multiple isolates.
This is consistent with results of a recent genomic study of multiple Arabidopsis accessions noting that R genes were the group of genes exhibiting the greatest level of genetic variability across accessions [ 32] and R genes are known to be subject to local adaptation [ 33, 34].
Studies have identified multiple genomic changes and revealed the degree of intra-tumoural heterogeneity in DCIS.
Complete distillation of the extensive findings of potentially causative mutations will require expression database analysis (e.g. http://hereditaryhearingloss.org/main.aspx c=.HHH&n=86597), functional assays in cell and animal models, meta-association analyses of integrated data from multiple genomic studies, and development of novel methods for discerning combinatorial effects of variants.
One of the most common copy number gains reported in multiple genomic studies of DIPG and pediatric GBM is that of PDGFRA [ 17, 18, 26].
The current study demonstrates the utility of employing multiple genomic markers for addressing and untangling the evolutionary history of reticulate groups.
Recently Brannon et al. have integrated data from multiple genomic studies and have observed that one of the major sub-types clearly segregates along gender lines [ 24].
These results confirm the involvement of common variants in multiple genomic regions in regulating IOP and/or glaucoma risk.
This study established a new successful approach to increasing ethanol production from glucose in S. cerevisiae by homologous overexpression of PHO8 gene due to multiple genomic insertion events.
As an alternative to large-scale variant validation studies, we developed the Recalibration and Interrelation of genomic sequence data with the GATK (RIG) workflow to integrate information from multiple genomic sources and identify reliable sets of variants.
Recently, major genomic studies further investigated the heterogeneity of breast tumors using multiple genomic technology platforms and approaches [ 10– 16].
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CEO of Professional Science Editing for Scientists @ prosciediting.com