Suggestions(1)
Exact(1)
The "OFF/ON" gene switches allow for the expression of cytotoxic and dominant negative proteins [6], for the ability to reverse the expression of the target gene [7], for the study of "gain of function" and "loss of function phenotypes" [8] and for the ability to isolate protein targets of transcription factors [9].
Similar(59)
Stable transgenesis for the study of gain-of-function mutations is a popular approach in zebrafish using the efficient Tol2 transposon system (Suster et al., 2009).
Although the study of gains in muscle mass is still relevant, only the assessment of crucial outcomes such as muscle strength and functional status will address clinical problems like the increased dependency that many older adults experience.
Nevertheless, these results can be used for devising experimental studies of gain-of-function by tumor suppressors mutated in specific sites (hotspots) and/or specific tumor types with particularly strong evidence of positive selection.
Although FcγRs are clearly implicated in the development of lupus in genetic studies of gain-of-function and loss-of-function mutations and copy numbers of FcγR genes, their role in predisposition to lupus nephritis and/or tissue injury is not as clear [ 29- 32].
Moorman PG, Schildkraut JM, Iversen ES, Myers ER, Gradison M, Warren-White N et al. A prospective study of weight gain after premenopausal hysterectomy.
In the contrary, there were no modulations by the genetic polymorphisms under study of the gain FRN amplitudes (p values > 2).
IL, TAH, and VPH conceived this post-hoc study of weight gain, IL designed the statistical analysis plan and conducted the analyses.
It was the aim of this study to gain insight into possible effects of this intervention.
The study of music gained a new dimension: performance informed by insightful analysis.
We did not conduct a controlled study of learning gains, but exam scores were not much different from year-to-year.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com