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Weight did not differ between groups or study occasions (P > 0.05) (data not shown).
Individual pharmacokinetic parameters can change between study occasions (Supplementary Data online).
For the liver, voxel sites were matched at the study occasions.
Hyperinsulinemic euglycemic clamp studies were performed the day after the second and third study occasions.
Twelve patients were measured twice on two consecutive days by the same observer on both study occasions.
On both study occasions (A and B), 12 adult subjects were recruited through support groups for people living with HIV.
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Thirteen patients were studied on the first study occasion only, and seven were studied twice.
Thereafter, oral information was provided on an ongoing basis before each study occasion.
Tolerability was assessed daily by the clinician during each study occasion (using an adverse-event report form) and at the follow-up visit 1 week after last study occasion (using an adverse-event report form and laboratory assessment).
Using the best and worse TEM per observer or study occasion we calculated 95% confidence intervals (CI) [ 18, 23, 24].
Subjects were randomly assigned to partial sleep deprivation on either the second (n = 4) or third (n = 5) study occasion.
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