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Beside the insufficient sample size consequent to early study interruption, our study has other limitations.
According to this single-center study, interruption episodes during EN in the ICU are frequent, the reason and duration of the interruption varied, and airway procedures had relatively longer durations of interruption.
After study interruption, we re-calculated the sample size based on the actual rates of failure and found that 790 patients would be overall necessary to properly set a future study, which makes this clinical trial unfeasible in a single center.
Another factor of interest in the current study, interruption of post-disaster obstetrical care, significantly increased mothers' risk for depressive symptoms.
The individual reasons for the study interruption are patient death or the withdrawal of the patient to participate in the study.
The individual reasons for the study interruption are the patient dead or the withdrawing agreement of the patient to participate in the study.
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Hopkins said that the measure was extreme: it is already taking action to correct its deficiencies, it said, and patients with cancer and other serious illnesses could be harmed by the studies' interruption.
A new "next-generation" sequencing platform, single-molecule real-time (SMRT) sequencing, suited for sequencing of long, repetitive DNA sequence [ 120], is a promising approach for studying interruptions and epigenetic marks in the expanded DM1 alleles, as additional factors influencing germline and somatic repeat instability and phenotypic expression of the disease.
In that study, daily interruption of sedatives was associated with a prolonged duration of mechanical ventilation (almost three days), ICU length of stay (seven days), and length of hospital stay (eleven days) [23].
Each of the AEs occurred once in each of two patients, and resolved by adequate concomitant therapies or the study drug interruption.
If data collection covers a period of 7 days, as in our study, any interruption of intake can lead to prevalence rates being underestimated.
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