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Protocols that use different types of cell cultures and other methods have been devised to study eye and skin irritation.
Although extensive research to study eye movements has been performed, this is the first study that considers differences accross image categories.
Different commercial kits have also been developed to study eye and skin irritation, based on the action of chemicals on these tissues.
If both eyes were equally affected, the study eye was chosen at the investigator's discretion prior to randomization.
In patients with bilateral uveitis, the eye with more advanced disease was chosen as the study eye.
As a comparison, in this study, eye tracking achieved a sensitivity of 88%, quite comparable to tests used to screen for heart attacks.
Those who refused fellow eye surgery had lower fellow eye IOP and were more likely to have had hypotony after study eye trabeculectomy.
Group 1 received intravitreal (IVT) injections of 352 μg of sirolimus in the study eye on days 0, 60, and 120.
Group 2 received subconjunctival (SCJ) injections of 1,320 μg of sirolimus in the study eye on days 0, 60, and 120.
The primary bioactivity analysis was conducted at month 6 and was evaluated by assessing the proportion of patients achieving a complete or partial response in the study eye.
The first patient was lost to follow-up after cataract surgery in the study eye that was performed after receiving the second scheduled dose of sirolimus.
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