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This became the patient's study exit date.
Patients who did not reach the outcome of interest were censored at their study exit date.
Patients without CVD at the baseline date will be followed up until the time of a CVD diagnosis if it occurs before the study exit date.
Accrued person-years were calculated for the cohort, with study entry date defined as date of birth, and study exit date the earliest of (1) first invasive non-TGCT cancer, (2) death, or (3) study cut-off.
The number of person-years each participant contributed to the cohort (defined as the number of years between completion of the 1987 questionnaire and their study exit date) served as the underlying time metric.
Time at risk for a subsequent primary breast cancer began at 5 years subsequent to RB diagnosis and ended at the earliest of: (a) the patient developing invasive breast cancer; (b) the first occurrence of loss to follow-up; (c) death; or (d) reaching the study exit date, December 31 , 2005
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Cohort members remained in the study until their exit date, which was the earliest of the following dates: 31 December 2007, date of death, or date of first cancer diagnosis.
Age was defined in days from birth date to diagnosis date, and study exit was defined in days from diagnosis date to end of follow-up interval or death, whichever came first.
Time was calculated from the ANC registration date (or reported pregnancy date if ANC registration date was unknown) to the CTC registration date (or date of next visit to the CTC if already registered), or date of exit from the DSS (out-migration, death or enumerated in the latest round), or end of the study period (Dec 31 2012) if this preceded the DSS exit date.
An additional 296 patients were excluded because of missing dates for age, study entry, or study exit.
In case of study exit, attempts will be made to obtain at least vital status and dates of unplanned cardiovascular hospitalizations.
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