Sentence examples for study designed to define from inspiring English sources

Thirty-six patients with advanced hematologic malignancy were entered into a phase I study designed to define a tolerable dose of busulfan (BU) and cyclophosphamide (CY) combined with 12 Gy of fractionated total body irradiation (TBI) as preparation for marrow transplantation from HLA-identical siblings, 0-1 locus HLA-non-identical family members or autologous cryopreserved marrow.

The HIM study was a U.S.-based cross-sectional study designed to define the prevalence of hypogonadism in men aged >45 years.

We utilized a study designed to define purely T-regulated transcription, purely genotype-dependent transcription and transcription dependent on both T and genotype, with interaction or no interaction between these variables.

In a study designed to define the threshold level of GR needed to trigger apoptosis in cell lines, these same patient samples were analyzed an additional time using QRT-PCR, and this study yielded similar results [25].

We have recently completed several studies designed to define the mechanisms regulating UPase expression and better characterize the multiple biological effects of uridine.

This constitutively active chimeric protein will be useful in future studies designed to define the components of signal transduction pathways modulated by PECAM-1/SHP-2 signaling complexes.

Consistent with this concept, studies designed to define pharmacological properties of stable PGI2 analogs revealed that beneficial effects of these compounds appear to be mediated, in part, by activation of PPARδ.

Further studies designed to define the determinants of risk for acquiring salmonella bacteremia are warranted.

Of note, clearance after successful infection has not been observed in 18 volunteers in previous studies designed to define the infectious dose of the present challenge strain.

However, additional biochemical and clinical studies designed to define a range or threshold level of AGAT inactivation, for which to target with modulating strategies, will undoubtedly facilitate the development of temozolomide dose-schedules with superior therapeutic indices in those tumour sites, where methylating agents have utility (Friedman et al, 1998).

The results of numerous studies designed to define conditions for the inactivation of PrPSc concluded that protein denaturants, such as sodium dodecyl sulfate (SDS) [ 13, 14], are effective in reducing infectivity, but that complete inactivation requires extremely intense conditions, such as 1 h of autoclaving at 134°C or treatment with 2 N NaOH or sodium hypochlorite for 1 h [ 12].