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This study attempted to improve on some study design weaknesses of previously published work in this field.
21 27 The study design weaknesses and the enormous placebo effect in osteoarthritis clinical trials as well as the specific characteristics of the HA used can account for these contradictory results.
The recent study by Morden et al. (6) exploring associations between insulin, glargine, and incident cancer in the older patient Medicare database has unfortunately perpetuated these study design weaknesses, and contrary to the authors' conclusions, the results are far from reassuring.
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Our study's weakness results primarily from the observational study design rather than prospectively collected data.
The investigators appropriately recognize that matching of chronic disease states would enhance the study [ 1], but this omission might be of more significance than a simple study design weakness.
We observed common study design and weaknesses in the methods, which substantially reduced the ability to determine causation and attribution of the interventions.
Of these surgically treated subjects, 586 (85%) had a significant cough response.28, 29, 36, 46, 47, 48, 49, 50, 51 These studies have design weaknesses including lack of blinding, lack of controls, use of highly selected patient populations, and different postoperative follow-up procedures.
As Table 2 shows, most of these studies suffered design weaknesses that limit the inferences that can be made about these findings and the extent to which the results can be generalized.
The study design has inherent weaknesses, which were difficult to avoid because of feasibility issues.
However, the study design also has weaknesses that must be accounted for in the interpretation of the results.
The study design had some weaknesses, one being that the sample sizes were moderately large, especially the 1992/93 cohorts (see Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com