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This article demonstrates how a simple study design flaw has proved to be the Achilles heal of this entire line of research.
While this is not a study design flaw, it could change the question asked about factors influencing sedentary behavior and chronic disease risk in human populations.
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However, study design flaws hinder formal technology assessment.
However, major study design flaws and limitations in this investigation overshadowed the findings which failed to demonstrate a benefit in using the bipolar sealer over the standard electrocautery method.
While provocative, study design flaws limit the generalizability of the later studies.
These results have been widely criticized on the basis of study design flaws.
Previous studies identified a number of study design flaws and bias that give rise to underestimation of the real risk in epidemiological studies, particularly in those funded by industries [ 76, 77].
Furthermore, small sample size, study design flaws or other biases may be more common reasons than true racial heterogeneity for the observed discrepancies between studies addressing genetic risks [ 64, 65].
Many studies have investigated the association between objectively measured physical activity and obesity in children; however results have been inconsistent [ 7, 8], probably due to inadequate measurements of physical activity and body composition [ 9] or study design flaws [ 8].
Empirical observation of the quantitative effects of study design flaws on the findings of diagnostic studies has shown that case-control designs, studies that use different reference tests for positive and negative results of the diagnostic test under study, and lack of blinding led to overestimation of diagnostic test accuracy [ 67].
The study design was flawed and thus compromised the results and conclusions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com