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Critical appraisal of methodological bias revealed consistent shortcomings in study design and execution.
Here, we synthesize relevant concepts and extant methodologies to guide investigators in study design and execution.
Guide to Community Preventive Services Community Guidee) criteria were used to assess study design and execution.
Trial-specific factors, such as subject selection, study design, and execution strategy, have an impact on the outcome of trials.
This could be due to confusion in cell product terminology, complexity of clinical study design and execution or agreement on meaningful outcome measures.
Overall, Wuqinxi monotherapy or combination therapy can improve pain symptom, but the effect on BMD owing to poor study design and execution, inconsistency and imprecision is uncertain.
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EL, PPO, MVL, PAN also all made important contributions to the data contained in this article and were involved in the studies design and execution.
V.L.B. contributed to the study design and study execution and wrote the manuscript.
A steering committee (see online supplementary appendix 5) is responsible for the study design and scientific execution of the study.
CT, KB, MC, and LC were paid consultants to Allergan and assisted in development of study design and manuscript execution.
JJDL conceived the study, design and coordinated execution, performed data analysis and interpretation, wrote and gave final approval for manuscript submission.
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