There are two significant results of this study: the demonstration that OH-PCB congeners are carcinogenic, and that the type of CV tract tumors observed in response to treatment with a mixture was significantly different than from those found after individual OH-PCBs treatment.
The ultimate value of these studies awaits demonstration that crop improvement can be advanced by manipulation of this interesting class of genes discovered by genomic screens for selection.
Based on the current study, our demonstration that HP1γ, a well-known epigenetic regulator, undergoes robust phosphorylation at Ser in G2/M has significant biological relevance and deserves careful consideration.
In this study, the demonstration that calcipotriol was also able to upregulate ERα gene expression in an ER-negative breast cancer cell line, suggest that treatment options in breast cancer patients might also include vitamin D analogues with reduced side calcemic effects.
A particularly novel finding of our study was the demonstration that β3 integrin induced TβR-II tyrosine phosphorylation via Src kinase.
A key finding in the present study is the demonstration that PM not only induces AHR in naive mice but also is synergistic in exacerbating AHR in mice with preexisting enhanced AHR (OVA-sensitized mice 4 days after PM exposure).
The major result provided by this study is the demonstration that DMSXL mice, a transgenic mouse model of DM1, have respiratory impairments characterized by a significant decrease in RR, TV, MV and SpO2 compared with control mice.
Within the category of 'Selection,' one item was excluded for cohort studies and one item was excluded for case control studies, namely 'Demonstration that outcome of interest was not present at start of study' and 'Definition of controls: no history of disease (endpoint),' respectively.
In previous molecular epidemiological studies, unequivocal demonstration that anelloviruses are implicated in the pathogenesis and severity of disease is still lacking or is poorly demonstrated [ 15, 16].
Beyond demonstrating the synergistic effect itself, the importance of this study lies in the demonstration that observed synergy is accompanied by cell signaling changes that are unique to the combination of the two compounds.
