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With each study deleted from the model once, results remained statistically significant across all deletions.
The 20 deletion variants investigated were a subset of CNVs that met the following criteria in our previous study: deleted compared to the reference sample, called in ≥2/50 samples, common boundaries, and estimated size <3 kb as predicted from the aCGH data (although the aCGH algorithm underestimated the size of some aberrations, thus 4 deletions were later found to be >3 kb).
With each study deleted from the model once, improvements remained statistically significant, ranging from 0.55 to 0.60.
The difference in g between the largest and smallest values with each study deleted from the model was 0.081 (26.0%).
With each study deleted from the model once, deceases remained statistically significant, ranging from −0.56 to −0.67.
With each study deleted from the model once, increases remained statistically significant, ranging from a g of 0.70 to 0.91.
Similar(44)
In that study, deleting all the detected targets (120 on average) slowed, destabilized, and then stopped the rhythm (Hayes et al., 2012).
In the current study, deleting the item "Demanded to have sex with me even though I did not want to (but did not use physical force)" would increase α for the sexual violence scale from 0.72 to 0.77.
However, because these studies deleted the whole AgRP neuron, and deletion of the neuron is a far greater insult than deletion of the peptide alone (41), the possibility of this effect being due to neuropeptides other than AgRP remained.
Lactate could be produced initially when cells are growing sub-optimally (which is probably why other studies deleted Ldh [ 26, 27]), but lactate production would be predicted to decrease as cells adaptively evolve to higher growth rates, which favor ethanol production due to differences in redox requirements (ethanol production consumes more NADH).
As anticipated from previous studies, deleting MRE11 did not suppress the DNA damage hypersensitivities of sae2∆ cells, revealing that mre11-H37R and mre11-H37Y were not behaving as null mutations (unpublished observation).
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