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Hazard ratios for all cause mortality were compared in both the BWHHS and MRC assessment study datasets and risk of first hospital admission and institutionalization was assessed using data that was only available in the MRC assessment study.
Approaches based on principal components factor analysis and different regression techniques have been compared for robustness over multiple study datasets and across enriched (amyloid beta 42-positive, apolipoprotein E4 allele carriers) and non-enriched populations.
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JE conducted the screening study, extracted data from the screening study dataset and drafted the manuscript.
ROC curves were constructed for the Nomogram and the MLR informed by CART model for the Bay Area SLN study dataset and the independent Northwestern dataset.
In this paper, we describe the methods we have used to assemble the study dataset and provide a description of the study cohort.
Two thirds of the practices were randomly allocated to the study dataset and one third was retained for a subsequent study.
We gained permission from The Sax Institute to use data from the 45 and Up Study dataset and ethical approval had been granted from the relevant ethics committees.
Information on other two (cooking duration and kitchen ventilation) however was only available in the study dataset and was not captured in the Indian NFHS survey.
So far, the Rotterdam Study GWAS dataset has been imputed to HapMap version 2 and 3 (with ~7.5 million resulting SNP genotypes in the Rotterdam Study dataset), and the 1000 genome dataset version 4 (with ~18 million resulting SNP genotypes in the Rotterdam Study dataset).
In each study dataset, and for both retrospective and prospective assessment, overall 'any fall' incidence rates were consistently higher amongst women than men and the 95% confidence intervals did not overlap.
Unfortunately, the quality of related data was poor in the study dataset and little interpretation of the results for referrals can be made without validation using other data sources.
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