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This fact enabled us to study concentrations that are close to regional background levels.
OP-1118 was dissolved and diluted in DMSO to achieve final study concentrations that ranged from 0.004 to 128 μg/mL.
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With respect to hazard identification, it is possible to detect adverse effects on male reproduction in a standard subacute study with concentrations that produce significant general toxicity.
These amounts were chosen in order to produce study drug concentrations that were similar to those achieved in the ECMO circuit.
These effects have been observed in human chamber studies at concentrations that may occur only in poorly ventilated kitchens with gas appliances in use (IOM 2000).
The concentration of TNF was adapted from previous animal studies, and doxorubicin concentrations that yielded no local toxicity were used.
In the current studies, we used concentrations that have been considered stimulatory on pancreatic ducts [ 27, 28].
Nearly all of the laboratory studies involved high concentrations that are not reflective of typical environmental exposures.
Adsorption was studied at concentrations that correspond to low surface coverages and in the presence of volatile solvent diluents.
For these reasons we used in our study the lowest drug concentrations that produced a clear mitotic response.
These studies, however, have reported mercury concentrations that exceeded our definition of low-level exposure.
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