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We study closure and decision properties of the pseudoknot-generating operation.
Ultimately, in our hospital, three patients were included before the study closure.
Seven patients were still alive at study closure and survival was censored for these patients at a common date (April 8 , 2015.
By the date of study closure, 34 participants assigned to no therapy had commenced continuous ART compared with 23 in the IL-2 alone and 14 in the IL-2+ART groups [figure 3(a)].
Stavudine was given as 40 mg or 30 mg (depending on body weight) twice daily until the last 3 months (from the study closure) when the 40 mg became obsolete because of an increased toxicity[11]; 3TC as 150 mg twice daily; and NVP 200 mg daily for the first two weeks and then twice daily after that.
Planned study closure, Oct/Nov.
At study closure, six patients with MCL continued receiving lenalidomide.
Patients were observed until death or study closure.
Treatments were given until disease progression, unacceptable toxicity, or study closure.
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Interim data for several phase 3 trials of gefitinib or erlotinib monotherapy versus doublet chemotherapy were favorable enough to warrant early study closures, with subsequent treatment crossover as a confounding factor in the analysis of OS.
Before these studies, CLOSURE I 23 (the first randomized study) did not show any significant changes in the study endpoints among patients treated with drugs and those who underwent PFO closure by the Starflex device (NMT Medical, Inc., Boston, MA, USA).
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