However, the great majority of the literature is composed of retrospective observational data, often in the form of single-center studies with relatively small numbers of subjects.
On the other hand, in regard to the disease areas where only Japanese studies were available, the application of the Japanese National Health Insurance was based on a small number of studies with relatively low quality scores.
Oral dosing with BGC20-1531 (200 and 400 mg) in healthy volunteers has resulted in consistent plasma exposure in previous clinical studies with relatively low inter-subject variability (unpublished observations; single ascending dose study Cmax 9,850 ± 2,900 and 22,700 ± 5,500 ng/ml at the 200 and 400 mg dose, respectively).
Phylogenetic studies with relatively few taxa have a major advantage in terms of exploring a variety of analytical methods [22], [44] and all possible phylogenetic reconstructions.
[17], [26] The three sensitivity analyses showed that excluding studies with relatively low scores on the quality assessment scale resulted in similar HRs (Table 1, Analyses S1 S3).
These automated measures have been compared to manual tracings as the reference standard in only a few studies with relatively small sample sizes.
Several researchers have then tried to find polymorphisms that may have been correlated with AD and that avenue of research has not been highly prosperous [38] [42], but there exist some studies with relatively positive results [34], [41], [42].
This caveat applies to high-resolution studies with relatively long image acquisition times; in this study, the short image acquisition times for low-resolution data resulted in distortions always less than a voxel.
However, these conclusions are predominantly based on two studies, with relatively small sample sizes.
Many of the trials in this review are observational studies with relatively few enrolled patients.
Future research should include more studies with relatively longer follow-ups to investigate recurrence rates and survival outcomes.
