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It is worth noting that health care decisions are often made on an ad hoc basis rather than using a specific framework like MCDA or PBMA – our review includes all published studies, which likely overrepresents the frequency with which these two approaches are used.
There are several differences between the study reported here and previous studies which likely influenced the results.
There are several major differences between the designs of our studies, which likely account for the novel results that we are reporting with p21.
Participants and study personnel were not blinded in any of the three studies, which likely contributed to differential rates of loss to follow-up.
These rates are higher than those reported in population-based studies, which likely reflects the fact that some of these patients may have been referred due to OSD symptoms or may have been treated with multiple preservative-containing eye drops [ 25].
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This argues for lower than 7% misclassification in our study, which probably is not likely to have substantially increased the risk of a type 2 statistical error.
Norovirus diagnostics improved over the study period which likely resulted in increased reporting.[18] To account for this, a term representing the proportion of diagnoses each year made by molecular techniques (PCR or ELISA, as opposed to electron microscopy) was included, which increased from zero in 1993 to 99% in 2006.
A considerable proportion of the individuals with asthma or COPD did not have any medication prescribed during the study period, which likely indicates under-medication [ 9, 21].
It suffices to note that there was some heterogeneity between the study samples, which likely resulted from the different settings and purposes for which the samples had been collected.
Similarly, there was no difference in fledgling survival between the two major breeding sites (Carden and Dyer's Bay) during the study period, which likely reflects the similarity in management, as both sites adhered to the WPC protocol and WPC trained all the staff.
The protocol used in the I-ELCAP research was reviewed semi-annually and modified over time and with increasing experience in the analysis of the study data, which likely impacted the volume of procedures indicated in years subsequent to the baseline year because of a temporal, learning effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com