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Population PK assessments in phase 2b and phase 3 studies which characterize PK differences between different age groups, clinical disease states, and human populations can then be combined with the PK-PD observations to provide a sound evidence base for dose recommendations in different target groups.
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For a model glass-former (a binary Lennard-Jones system), MD studies which characterized in detail the movements of the different particles led to the discovery of dynamical heterogeneities.
Essentially, we have carried out a retrospective genotype-phenotype analysis based on previously published studies which characterized the phenotypic traits of patients with deletions encompassing DIA1R.
Data collected as part of a U.S. Army DU aerosol characterization and risk assessment study, which characterized DU aerosols created by the perforation of an Abrams tank and a Bradley Fighting Vehicle with a large-caliber DU penetrator, indicate that soldiers in friendly fire incidents inhaled DU that was a mixture of soluble and insoluble DU oxides (Parkhurst et al. 2005).
As a next step of the previous study which characterized the distinct composition of ganglioside molecular species between axons/dendrites and soma of neuron in vitro [33], in the present study, we demonstrated that gangliosides with differences in their ceramide moieties showed distinct distribution patterns in the mouse brain, especially in the hippocampal formation in vivo.
This is the first study, which characterizes different aggrecan fragments in human serum.
To our knowledge, this is the first study which characterized the cellular origin of MPs in the course of ARDS, both in circulating blood and BAL.
The present study, which characterized the nature of progression of both CAC and AAC in older patients with a relatively long duration of type 2 diabetes, revealed several important findings.
These initial studies in astrocytoma/glioblastoma cell lines indicate that defects in primary cilium ciliogenesis do occur in glioblastoma cells and provided the impetus for this current study which characterizes the morphology of primary cilia and documents ciliogenesis defects in molecularly characterized human glioblastoma multiforme (GBM) tumors.
More recently, in a study which characterized a collection of 113 strains of P. freudenreichii, more than 25% of strains could not be assigned to a subspecies, and were labelled "pheno+" (lac+/nit+) or "pheno−" (lac−/nit−) (Dalmasso et al. 2011).
Only a few studies have been conducted which characterize the emissions from RWHHs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com