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Studies were terminated after 30 days of treatment.
Phase II/III trials of IMPDH inhibitors such as tiazofurin and benzamide riboside have been conducted with very promising results, although studies were terminated due to neurotoxic side effects [18], [19], [29].
The studies were terminated 12 – 15 days after the last drug dose.
Typically, studies were terminated when tumors in the control animals reached an average size of 2000 mm.
However, two parallel phase I studies were terminated early after a fatal case of toxic epidermal necrolysis.
The studies were terminated 12 weeks post infusion for intact animals and 18 weeks post infusion for ovariectomized rats.
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Organ and tissue toxicity and pathology are evaluated when the studies are terminated.
Most studies are terminated after 1 2 years.
One of the studies was terminated early because of false-positive alerts [ 34].
Surviving males and females in the drinking water study were terminated after 22 and 19 months, respectively.
As the experiments of the present study were terminated 24 h after the induction of peritonitis, sepsis mortality could not be assessed.
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