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These studies were substantially larger in terms of participants and used longer follow-up periods than the present study.
The sample sizes of these studies were substantially smaller than our study and information on confounders was limited.
Initial estimates for the age of this group from previous studies were substantially older, with mean ages of 120 mya [ 5] and 99 117 mya [ 8].
Mean IOP reductions in the control group in each of these six studies were substantially smaller than the -5.4 mmHg mean change from baseline to week 12 observed herein.
8 Larger differences in stroke risk between the sexes were found in the Framingham study (hazard ratio 1.9), Euro heart survey (1.8), and ATRIA study (1.5), 1 4 16 17 but these studies were substantially smaller than the present study.
As shown from the comparison between the CIs of AM-QTLs and the projections of the CIs from previous meta-QTL analysis carried out in hexaploid wheat, it was evident that the meta-QTL CIs from bi-parental RIL studies were substantially wider than those of the AM-QTLs, in the magnitude of 10 (minimum) to 30 cM (maximum) thus making it difficult to accurately infer QTL co-locations.
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(d) The number of observational bioclimatic model studies is substantially higher than that of experimental studies.
In both European and U.S. regulatory sectors, the preclinical requirements for first-in-human studies are substantially reduced for the situations in which doses are kept low to minimize risk to study participants.
Estimates from blood donor studies are substantially higher for five countries and lower for two.
The P value for a significant overlap between the two expression studies being substantially different from random studies is <10−16.
These studies are substantially larger than the phase II study and will provide much more information about the safety and tolerability of denosumab.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com