Of these, two large-scale studies (1320 patients) were observational and three studies were on one-lung ventilation settings.
Twelve studies included adding cells to ADM, 3 studies were on SIS, one study was on UBM, one study was on amniotic membrane, and one study included both SIS and ADM loaded constructs.
Twelve studies included adding cells to acellular dermal matrix (ADM), 3 studies were on small intestinal mucosa (SIS), one study was on urinary bladder matrix (UBM), one study was on amniotic membrane, and one study included both SIS and ADM loaded constructs.
Upon reading the full text of the remaining 14 studies, we found that 8 studies were on non-ICU patients and one did not provide data on bacterial infection; therefore, they were excluded, leaving us with 5 studies for analysis.
Temporal studies showed a significantly higher prey abundance in the absence of predators than spatial studies, perhaps because the temporal studies were on average longer than the spatial ones (temporal - 5 years, spatial - 1.67 years), giving time to capture prey response.
Seven studies were on pharmaceuticals, two were on surgery, one was on a mixture of interventions for intensive care patients, and one was on diagnostic procedures.
Colour Doppler ultrasound has been used to measure blood flow in osteomyelitis [4, 5]; both of these studies were on children with recent symptoms (2 15 days in one study, 2 10 days in the other), and both found elevated blood flow within or around the involved periosteum.
Some of the earlier studies were on limited years of data, and the earliest one used only breed-level data [ 3, 12, 13, 15].
Both studies were on mixed populations in secondary care settings with a one year follow-up.
Eleven studies were on men and women, three studies were on men, and one study was on women (Table S1).
Two of the studies were on subjects with seasonal pollen allergy [ 14, 15], and one study was on subjects with dust mite allergy and perennial rhinoconjunctivitis [ 16].
