Study of their works has been a thriving business for centuries under the name of patristics, although until recently these studies were largely the domain of seminaries, schools of divinity and departments of religion.
Earlier studies were largely based on small amounts of genetic data and were therefore unable to provide univocal answers.
Previous studies were largely focused on the BAL fluid level of MMPs (including MMP2, MMP8 and MMP9) and found an elevated expression pattern [35].
Studies of p53 mutations, p53 codon 72 polymorphism, and MDM2 SNpolymorphismphism are detailed in the Additional file 1, as the results of the studies were largely negative.
The included studies were largely of moderate or high quality, though two studies did not meet the minimum criteria outlined in the quality checklist and thus were deemed low quality.
However, for most of the genes evaluated, there was no effort to replicate findings and studies were largely modest in size, typically consisting of no more than a few hundred cases and controls.
Despite early concerns about multiple testing issues and power, GWA studies have brought the gene mapping successes for complex traits, which candidate gene studies were largely unable to deliver.
In the past decades, numerous research studies were largely focused on the synthesis of various non-Pt catalysts such as metallic oxide catalysts [7], non-precious-metal (Me-N x /C) catalysts [8], heteroatom-doped carbon catalysts [9], and graphene-porphyrin MOF composite [10] in order to replace the precious Pt catalyst.
This is not to say that just because they are an economist they did their analysis wrong, but the fact that these economists are out of their field of expertise is supported by the notion that these studies were largely published in economics journals (which have editors who don't understand the nuances of crime analysis or criminal behavior), or second tier criminal justice journals.
Both of the above mentioned studies were largely qualitative.
Tiwari and colleagues [19] employed a variety of cell types, including primary bone-marrow-derived macrophages and RAW264.7 macrophages, while our studies were largely on mouse primary embryonic fibroblasts.
