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Class I studies were defined as prospective, randomized controlled trials.
Class II studies were defined as prospective cohort studies, retrospective case-control studies, or clinical series with well-designed controls.
Class III studies were defined as clinical series without concurrent controls, or studies with appropriate single-subject methodology.
Other studies were defined as randomized according to the authors, but a thorough review revealed in reality severe risks of bias.
Of these, 14 studies were defined as 'gold standard' by the criterions defined in the 1991 ACCP/SCCM consensus conference [42], two by the third international consensus definitions for sepsis and septic shock (sepsis-3) [43], one by Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) [44], and another by American Burn Association ABAA) [45].
Controls for the various studies were defined as persons without a previous history of tuberculosis and were frequency matched for age, sex and area of residence.
Similar(23)
Within this tool, various house types (AgentschapNL reference houses, [14]) with reference dimensions based on comparative studies are defined.
Inconsistency across studies was defined by an inconsistency index (I) > 50%.
The recommended dose (RD) for phase II studies was defined as one level below the MTD.
Video studies was defined as those which descibed a evaluation of a video.
The goals of this case study were defined according to the Goal/Question/Metric (GQM) approach [59].
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