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The performed interaction studies were completely immune from interferences of other receptor domains not covered by the design, thus decreasing the possibilities of selecting potential ligands able to bind other subtypes of HER2 receptor family.
No studies were completely unsupportive.
However, the results of both studies were completely different in terms of LYG.
Eight studies were completely matched with respect to the reported clinicopathological parameters [ 12, 15, 16, 28, 30, 32, 35, 39].
Many disease-associated genes identified by GWA studies were completely unsuspected to be relevant - for example, the autophagy system in Crohn's disease [ 4].
We were able to confirm by contacting trial authors and checking review protocols that 4 studies were completely free of selective outcome reporting (i.e. clearly reported all outcomes measured).
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In this step, all studies are completely read.
For instance, crossover studies involves randomly assigning a sequence of interventions to different groups over the study period, therefore, the randomization technique used in crossover studies was completely different from that in RCTs.
However, also four US studies are completely negative [13], [14], [29], [30], accounting for about two thirds of the total patient sample recruited in North America (Table 2).
Taken together, data from the nude mice studies are completely consistent with our results obtained from the in vitro experiments.
The conclusions reached in meta-analytical studies are completely dependent on the quality of the data analyzed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com