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All CT perfusion studies were acquired with a GE Healthcare VCT 64-slice CT scanner.

The PET studies were acquired with a Biograph 6 PET/CT scanner (Siemens Medical Systems, Erlangen, Germany).

Studies were acquired with a Siemens/CTI (Knoxville, TN) ECAT EXACT HR 47 tomograph using the two-dimensional mode (interslice septa extended) (10).

One unenhanced and seven enhanced studies were acquired with an acquisition time of 1 min. Criteria for malignancy were signal enhancement of 90% or more within the first 2 min after bolus injection and signal plateau or washout phenomena afterward.

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On scanners with the capacity for prospective triggering, studies are acquired with this technique whenever heart rate is adequately controlled (HR<65) and regular.

The two sets of seismic data (SPr2 and OGr1; Fig. 1) used in this study were acquired with the same seismic system (Takahashi et al., 2009; Kodaira et al., 2010).

Except for the samples used to determine the best acquisition time, the rest of the 31P-NMR spectra of this study were acquired with 15 h of acquisition time.

First, all data in this study were acquired with the patient at rest and in a supine position.

All scintigraphic imaging studies were acquired as multi-isotope studies with a 20% window on the 364-keV photopeak of 131I and the 247- and 172-keV photopeaks of 111In.

Furthermore, in these studies data were acquired with ultrashort TE and a long TR, minimizing T2 and T1 relaxation effects, and, ultimately leading to very reproducible results with a high SNR.

In this study, CTs were acquired with IV contrast media, but from a mixture of conventional (10 mm collimation), and helical scanners (7 mm collimation, 1.5 pitch).

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