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The studies were abandoned in the early 1970s when drugs like LSD became used on the streets, leading to strict federal laws regulating them.
Some ongoing studies were abandoned after the dismal results of the PROPATRIA trial [ 55], and even the executors of the PROPATRIA trial thought that new randomized trials of probiotics in patients with predicted SAP were not warranted [ 56].
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However, government changes do not necessarily imply that studies are abandoned.
We also think that authors of proposals for pilot studies should be more explicit as to the criteria which lead to further studies being abandoned, and that this should be an important part of the proposal.
There is a lack of over-arching time targets for the entire RM&G process, in particular relating to CLRNs in England, an apparent lack of any requirement to respond at all, either to give or withhold permission, and, as a result, the higher likelihood of studies being abandoned, or reduced in scope and depth.
The environmental and consumer groups, backed by Representative Dennis J. Kucinich, Democrat of Ohio, demanded that the study be abandoned and begun again with a new panel of experts.
An ongoing trial in Guinea with the VSV vaccine found that it protected participants so well that the control arm of the study was abandoned after an interim analysis.
This joint study was abandoned two years later, Boeing's interest having declined because analysts thought that such a product was unlikely to cover the projected $15 billion development cost.
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In 10 of the first 18 patients, additional malignant lesions were found and the study was abandoned.
Early into the study, however, significant problems of subject recruitment and attrition affected the collection of data, and ultimately the study was abandoned [ 81].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com