To minimize the risk of selection bias, that frequently threats the validity of case-control studies, we selected controls randomly and continuously from the same geographic region as the cases.
For the evaluation studies we selected different ligand data sets containing known inhibitors of MAO and PAO.
The studies we selected are representative of the current literature, covering the past 15 years of work in three key areas of sepsis research.
In order to restrict our research to more recent studies, we selected the period from 1999 to 2015 and, for each keyword search, we analysed the first six pages of results, therefore avoiding any loss of relevance in the results.
By modeling studies, we selected positions to introduce additional disulfide bonds into ribonuclease A at regions that had proven to be crucial for the initiation of the folding or unfolding process, respectively.
For these studies, we selected the US FDA-approved mAbs cetuximab (Erbitux; Merck, Darmstadt, Germany) and bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA, USA/Hoffmann-La Roche Inc., Penzberg, Germany), directed against the epidermal growth factor receptor [EGFR] and the vasculature epidermal growth factor [VEGF], respectively, as the model mAbs.
Based on these studies, we selected an oral dose of 200 mg/kg in the subsequent nociceptive tests in mice.
For these studies, we selected two clinical strains of Mtb that differ in their abilities to induce an immune response in mice and in human monocytes [28].
For fixed-dose studies, we selected only those arms with optimum doses of second-generation antipsychotic drugs as reported in dose-finding studies (amisulpride 400 800 mg/day, olanzapine 10 20 mg/day and risperidone 4 6 mg/day) [20].
For our studies we selected the Burkitt's lymphoma Raji, the non Hodgkin lymphoma SUDHL-4, the B cell lymphoma DOHH-2 and the three multiple myeloma (MM) lines SGH-MM5, SGH-MM6 and RPMI 8226.
Finally, it could be argued that there is no direct proof that the serotype changes reported in the studies we selected are indeed due to capsular switch, as many events can go unobserved between two consecutive samplings.
