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Importantly, the Tat produced in this fashion and used for these studies was functionally indistinguishable from E. coli prepared Tat 1 72, and caused similar microglial activation of NF-κB related pathways as previously seen for E. coli Tat 1 72 (Text S1, Figure S1).
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The fixed effects model assumes that the included studies are functionally identical and therefore would only describe naloxone distribution program participants.
The results listed in Table 3 show that 11 of 26 candidate genes selected in this fashion were validated functionally, while only two other genes from the previous 550 k studies were functionally validated [ 18].
However, it remains to be determined if the relative up-regulation of Bcl-2 observed in our study is functionally connected to any antioxidant activity in A. millepora even slightly delayed in time.
The new MS loci identified in this study are functionally interesting.
With the exception of PTPN22.6, all isoforms examined in this study are functionally interchangeable in suppressing NFAT activity.
Approximately 2400 of the 6518 differentially expressed genes identified in this study are functionally uncharacterized (no hits), constituting important candidates for further investigation.
The results of blocking HER2/HER3 dimerization by HER2Mab in MCF7-HER2 cellsuggeststhatathehe recombinant HER2Mab used in this study is functionally similar to rhuMAB 2C4.
The 74 MMR gene VUS included in the verification study were functionally characterized in our previous studies [Christensen et al., 2009; Kariola et al., 2002, 2003, 2004; Ollila et al., 2008; Raevaara et al., 2005].
It was also noted by Venables et al. that many of the cancer-associated genes found in their study are functionally related to remodelling of the cytoskeleton and cell movement [ 55].
As has been previously reported, CD133+ cells isolated from liver cancer cell lines (including those used in the present study), are functionally distinct cells with increased ability to induce tumors in animal models [ 14].
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