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The fundamental methodological elements of the included economic evaluations were extracted, and the quality of the included studies was evaluated using the Pediatric Quality Appraisal Questionnaire (PQAQ).
The methodology of the selected studies was evaluated using GRADE.
Strength of studies was evaluated by a numerical scoring system (see the 'Quality assurance' section).
The text of all potentially relevant studies was evaluated in detail and assessed against eligibility criteria.
Quality of included studies was evaluated with Quality Assessment of Diagnostic Accuracy Studies tool.
The methodological quality of studies was evaluated using the Cochrane Collaboration risk-of-bias tool.
Methodological quality, including risk of bias of the studies, was evaluated using the PEDro Scale.
In addition, the conceptualisation of HS, HRQOL, and QOL in these studies was evaluated.
Heterogeneity across the studies was evaluated with Higgins' I 2 statistics at an alpha level of 0.05.
The quality of included studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale (Wells et al. 1999).
Methodological quality of the included studies was evaluated to be very low and none of them were RCTs.
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