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These studies uncovered a powerful tool for the derivation of ES cells from different mammalian species.
Our studies uncovered a large amount of variability in eg95 genes.
Recent studies uncovered a novel tumour suppressive function of PLA2R1.
These studies uncovered a dominant function of the SYT-SSX2 oncogene in redirecting differentiation of the mesenchymal stem cells.
Subsequent studies uncovered a variety of new functions for this kinase in growth factor and steroid receptor signaling, cytoskeleton remodeling, cell survival, oncogenic transformation, and gene transcription 13.
Computational studies uncovered a class of highly similar isoforms, which were related to tandem 5'-splice sites (5'ss) and 3'-splice sites (3'ss), yet with very sparse anecdotal evidence in experimental studies.
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Both studies uncovered an essential role of the splicing machinery in MYC-driven transformation, and identify multiple associated abnormal splicing events, including intron retention.
Carbone, M. et al. Combined genetic and genealogic studies uncover a large BAP1 cancer syndrome kindred tracing back nine generations to a common ancestor from the 1700s.
Additional mechanistic studies uncover a direct role of the homologous recombination (HR) pathway, a pathway essential for error-free repair of DNA DSBs, in reprogramming.
In summary, our studies uncover a class of bifunctional compounds that associate with the ER membrane to disrupt ER homeostasis.
These studies uncover a novel role for OBF-1 and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com