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3 4 Concerns were based on case reports of sudden cardiac death in stimulant users, plausible pharmacological pathways involving well established stimulant effects on heart rate and blood pressure, 5 6 7 8 9 and a limited number of observational studies too small to examine serious cardiac events.
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However, the study sizes of the component studies were too small to observe any statistically significant reduction in stillbirth incidence.
In four studies comparing acupuncture with massage, the massage worked better than acupuncture, but those studies were too small to draw statistically significant conclusions.
It is possible therefore that most of the included studies had too small a sample size in relation to the number of predictors studied.
Additionally, the number of participating dietitians in this study was too small to study more therapist-related factors in order to explain inter-practitioner variation (n=27).
Earlier studies were too small to indicate whether breast-feeding or the number of children were risk factors.
An explanation could be that the studies were too small to show a statistically significant difference.
Many of the original studies were too small to be considered as representative of a population.
Pooled analysis is a method frequently used in epidemiology when individual studies are too small to allow any definite conclusion.
Since the number of the identified studies was too small and too diverse for meta-analysis, we refrained from a statistical analysis.
Up-to-date, TTH is not correlated with any adverse pregnancy outcomes, even if sample size of the available studies are too small to achieve definitive conclusions [4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com