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To correlate animal studies to human disease, we need to understand what these differences are.
Weissman's team has received a $20 million grant from the California Institute for Regenerative Medicine to move the findings from mouse studies to human safety tests.
For example, one of the challenges of trying to move from mouse studies to human studies, Vilen learned, is that the molecular players are different.
The relevance of our studies to human breast cancer is highlighted by the finding that CCN6 protein levels are inversely associated with TβRIII protein in 64%of invasive breast carcinomas.
As we continue to strive to apply the findings of in vitro and animal studies to human disease and transition from genomics to proteomics, we will experience an ever-increasing need for human tissues.
Intensive Care Medicine Experimental (ICMx) will focus on experimental research, stretching from cell and in silico models, through in vivo and ex vivo laboratory studies, to human volunteer and patient studies, where the emphasis is on biology rather than on clinical outcomes.
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"The moral is that you can't generalize from mouse studies to humans".
Thus due to the differing biomechanics, caution is therefore advised when comparing results from rabbit studies to humans.
Therefore some caution may need to be exercised when extrapolating findings from rodent studies to humans.
How we translate these studies to humans is still an unanswered question.
This creates uncertainty regarding the applicability of these studies to humans.
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