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crRNA-protein crosslinking studies show extensive contacts between the Csm3 backbone and the bound crRNA.
While transcript and protein abundance may be related quantities, they are not strictly correlated, and recent genome-scale studies show extensive evidence for posttranscriptional regulation (Vogel, 2011).
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Although this observation seems unexpected given that our histopathologic studies showed extensive hemosiderin deposition in the reperfused but not in the non-reperfused NF, it might be explained by the possible overlap of oedema (causing T2 increase) and haemorrhage (causing T2 decrease) resulting in an apparent net zero T2 change compared to normal tissue in the reperfused model.
These studies showed extensive modifications supporting cellular changes, increased antioxidant production and the accumulation of compatible solutes such as raffinose and proline.
This time point was chosen based on previous studies showing extensive changes in gene expression across strains [ 19].
The mechanistic in vitro studies showed extensive evidence of the inherent ability of MWNTs-NH3+ to cross the BBB.
These studies showed extensive gene regulatory overlap between DHT and MPA through androgen receptor and none with progesterone.
Pathologic studies showed extensive inflammation in the central nervous system (CNS), with predominant lesions in the brain stem and spinal cord (7 ).
This observation correlates well with previously published morphological studies showing extensive dedifferentiation in the regenerating radial nerve at these time points [ 1, 7].
In fact, there is now a growing list of studies showing extensive gene flow at some loci, whereas other loci remain differentiated, probably because some genomic regions associated with species-specific adaptations and/or reproductive isolation are less prone to introgress [ 4, 5].
Immunohistochemical study showed extensive expression of luciferase in the U87-luc cells of intracranial tumor tissues (Fig. 1A).
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