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Available scans were obtained from three studies: PROFILE 1001, PROFILE 1005, and PROFILE 1007 (scans were not included from PROFILE 1014 because this study was still blinded and enrolling patients at the time this analysis was undertaken).
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Teschendorff, A. E. & Widschwendter, M. Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions.
Furthermore, the design of the studies profiled by Snell et al. were called into question.
To date, two studies profiled the miRNAs in the whole inner ear and whole cochlea and vestibule [30], [31].
Therefore, future studies profiling discrete differences in matrix components are warranted.
Two clinical studies profiled miRNA expression in bronchial epithelial brushings from asthmatic adults [ 37, 38].
Finally, two studies profiled changes in gene expression after manipulations of activity in the central auditory pathways.
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