Sentence examples for studies of this variant from inspiring English sources

But subsequent replication studies of this variant carried out in Italian Caucasian population failed to identify the association of rs548294 with migraine.

YH exhibited an excited-state decay significantly slower than that of WT, consistent with single-molecule studies of this variant.

49, 50 A substitution of the small R group of serine with the aromatic R group of tryptophan would thus be predicted to interfere with the active site, and studies of this variant demonstrated a compromise between stability and activity.

Studies of this variant with EMSA and luciferase assays showed a higher affinity for transcription factors and an increase of 2.5 times in LDLR transcriptional activity (T-allele vs C-allele).

Participants in the Dutch replication samples included in our original study of this variant were excluded from analysis (n = 914 from NL4 study).

An association study of this variant in a large population will aid in understanding the potential role of the SLC15A1 gene in Bipolar disorder.

Our results provide evidence of the existence of a coding variant associated with obesity although further functional studies of this genetic variant remain to be performed.

Analysis of the 3D model and in silico docking studies of this enzyme variant suggest that substitution of Asp by Gly produces a wider entrance tunnel that would allow for a better and tight accommodation of larger substrates, thus justifying the experimental results obtained.

Detailed kinetic and inhibition studies using this variant of full-length NS3 can increase the understanding of the enzymatic characteristics of NS3, reveal the importance of the substituted amino acids and the significance of the genetic variability for design of effective inhibitors of the virus, and is thus of relevance for drug discovery.

Although the majority of the studies analyzing this variant found no association with cancer [ 12, 38, 42- 44], some studies reported an association with breast cancer [ 8], basal cell carcinoma in men [ 45] and a recent meta-analysis of this variant in bladder cancer revealed a significant association after controlling for potential bias [ 46].

Further study of the variant in other patient cohorts and exploration of the functional effects of TM6SF2 on inflammatory response will be needed to address this point.