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At NIGMS, we view systems biology research as relating to complex biomedical problems characterized by emergent behavior that cannot easily be inferred from studies of components in isolation.
In agreement with inferences drawn from studies of components of the cytoskeleton, endomembrane, NPC, and spliceosome [ 17- 19, 62- 67] a number of key RNA nucleocytoplasmic transport factors can be traced to the LECA.
A general concern of the reviewers was that only someone with considerable background in this field can follow the description and relate it to what is known from high resolution studies of components—e.g., the crystallographic studies the assembly platform (Karuppiah, et al)., secretion complex (Burckhardt, et al)., and fiber (Karuppiah, et al. and Craig, et al).
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The chapter briefly describes different types of wear such as abrasive wear, erosive wear, and adhesive wear, which is followed by case studies of component failures due to wear in service.
This manuscript addresses a spectrophotometric characterization of glazings for the study of components for the design of a modular façade system based on the climate of Portugal.
This chapter describes methods developed and employed for the study of components of the apoptosis machinery, utilizing the budding yeast Saccharomyces cerevisiae.
We have conducted a protein interaction study of components within a specific sub-compartment of a eukaryotic flagellum.
A more detailed study of components involved in signal transduction was performed by analyzing ESTs classified under the biological process term Signal transduction.
This work highlights the potential use of zebrafish larvae in the study of components of IBD pathogenesis.
In 1956 with the continuing development of faster and more complex computing machines, a realistic study of component misfiring in computers was made.
Interaction systems were proposed and implemented by Sifakis et al. as a model for the design and study of component based systems.
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