The large variation between studies makes it difficult to accurately compare complication rates to standard plating techniques.
The lack of high-quality studies makes it difficult to draw firm conclusions regarding the management of MOH [8].
However, the lack of properly designed clinical studies makes it challenging to formulate evidence-based practice recommendations.
The paucity of long-term studies makes it difficult to evaluate the sustained abstinence over time of smokers who quit.
Our study has several limitations: (1) The absence of any scoring system in most of the studies makes it difficult to correlate expected mortality with final results.
However, the large number of potentially confounding variables in such studies makes it difficult to conclusively implicate artificial surfaces in higher rates of ACL injuries.
Although the pilot nature of many of these studies makes it difficult to directly compare outcomes, results of these 23 studies can help guide future efforts to develop more effective, engaging, and evidence-based digital interventions for headache.
In addition, the mix of badges, levels, leaderboards, progress, feedback, status and avatars used in the conclusive studies makes it hard to know which of these elements actually worked.
The ultrafast disintegration of the U-D-WAF matrix with desirable mucoadhesivity in in vitro and in vivo studies makes it suitable for effective and rapid oramucosal drug delivery.
However, the diversity in the design of these studies makes it difficult to draw conclusions, and this precludes any general rules as to the reproductive and developmental toxicity of engineered nanoparticles.
Evidence from anthropological studies makes it clear that some mental illnesses are expressed differently in different cultures and it is also clear that non-Western cultures often have a different way of thinking about mental illness.
