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Several studies indicated increased expression levels of MCP-1 in the spinal cord of sporadic ALS patients and SOD1-mutated mice [ 20].
Previous studies indicated increased resistance to hormonal and cytotoxic therapies, and a poorer prognosis for patients with tumours overexpressing HER2 (Nicholson et al, 2001; Slamon et al, 2001).
Initial concentration range-finding studies indicated increased dendritic length and branching at concentrations as low as 2 pM; however, these effects were no longer evident at concentrations ≥ 2 μM.
Other a priori outcomes of interest for which previous studies indicated increased risks with respect to PCB exposure included mortality from all cancers [ 5], non-Hodgkin's lymphoma (NHL) [ 6], and breast [ 7], skin (melanoma) and brain cancer [ 8].
Previous studies indicated increased ROS production in newborn neurons (Tsatmali et al., 2006), and we aimed to quantify ROS in newborn neurons in the newt brain but this was not feasible due to technical reasons.
A couple of local studies indicated increased risks on malaria were associated with proximity to water development schemes [ 17- 19] all those studies were of cross-sectional nature in design to capture temporal influence.
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Transcranial magnetic stimulation (TMS) studies indicate increased GABAB receptor activity in patients after recurrent mTBIs (Tremblay et al., 2011).
While no significant trends have been found in either the annual number of reliably reported tornadoes or of outbreaks, recent studies indicate increased variability in large economic and insured losses from U.S. thunderstorms, increases in the annual number of days on which many tornadoes occur, and increases in the annual mean and variance of the number of tornadoes per outbreak.
There are conflicting reports on the effects of deforestation on catchment hydrology with the majority of small catchment studies indicating increased runoff and low evapotranspiration while studies of large basins have shown no such changes.
Although reliable prevalence data are lacking, recent studies indicate increased risk of microsporidial keratoconjunctivitis in the rainy season [5].
BACKGROUND Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use.
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