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Guibin Zou carried out the protection principle studies, drafted the manuscript.
initiated and carried out the molecular genetic studies, drafted the manuscript and approved the final manuscript.
J-EL carried out the molecular genetic studies, drafted and revised the manuscript.
SH conceived the project, performed initial functional studies, drafted and revised the manuscript.
JQ carried out the molecular genetic studies, drafted the manuscript, and participated in its design.
JSY and MP participated in the pharmacodynamic and mechanic studies drafted the manuscript.
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SA conceived of the study, drafted proposal and corrected manuscript.
BVR: conceived the study, drafted the manuscript.
VMM conceived and designed the study, drafted the manuscript.
BM initiates and design the study, drafted the manuscript.
MEAY directed the study, drafted and revised the manuscript.
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