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Larry Downes, an industry analyst who studies disruption and is author (with Paul Nunes) of the recent book, Big Bang Disruption, says it might be a mistake to say that IBM has reinvented itself completely over the years, even though he agrees that it has found ways to alter its direction enough to stay profitable and thrive.
Consistent with human studies, disruption of Comt in male mice elevates dopamine levels in the prefrontal cortex [2] and enhances working memory [30].
In previous studies, disruption of several M. oryzae hydrophobin genes, including MPG1 and MHP1, resulted in a water- or detergent-soaked easily wettable phenotype [64], [65], [66], [55], [67], [68], [69].
Also in animal studies disruption of TH by DDE is reported, although generally also an inverse association is observed [ 30, 31].
Specifically, using dye transfer studies, disruption of CENP-F function inhibits trafficking of connexins, resulting in loss of cell-cell coupling (Pooley et al., 2008).
Based on mouse KO studies, disruption of Syn isoforms is associated with an altered excitatory/inhibitory balance with serious consequences in postsynaptic integration, network computation, excitability and activity-dependent plasticity.
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In each of these studies, disruptions in the organization of the Müller cell have been noted.
In every other case he's studied, disruption has wrung two-thirds of the overhead primarily administrative, marketing and research costs—out of the business.
In this study, disruption of the compound action potential (CAP) and endocochlear potential (EP) by cyanide and CO was compared in rats treated with potassium cyanide (KCN) (7 mg/kg ip), saline, CO (35 ml/kg ip), and air.
In this study, disruption of PDK1 in AGRP neurons by the Cre recombinase gene, under the control of the Agrp promoter, occurred at 2 3 weeks of age [10] and did not cause apoptosis of AGRP neurons.
In this study, disruption of the TTHA0540 gene had no significant effects on global mRNA levels.
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