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However, this dichotomy is not always present as can be seen in the studies discussed previously.
Lesion analysis also avoids the difficulties in using overt and covert speech in functional imaging studies, discussed previously.
As with the 'life course' epidemiology studies discussed previously, the cost of multicentre RCTs must be balanced by efforts to maximise added value.
An epigenetic link to overweight and T2D is in line with the epidemiological studies discussed previously [ 14, 15, 17, 18, 26].
This mimicked the pre- and post-intervention suicide studies discussed previously where typically a larger amount of pre-intervention data was available than post-intervention.
The studies discussed previously suggest that microenviromental changes (i.e., niche deterioration) are critical for loss of stem cell maintenance or to drive differentiation over self-renewal and vice versa.
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In addition to the limitations of this study discussed previously (attrition, measurement error and regression to the mean), small numbers of those restricted at baseline for some individual items (such as self-care) and the consequent unstable estimate of change, may explain these inconsistent relationships between age and restriction patterns over time in some aspects of life.
Thus, it is likely that the putative absence of a legacy effect of improved BP control reported in HDS was a result of several limitations of this study (discussed previously), and it does not reflect a real lack of long-term benefit of early BP lowering in diabetes.
The state-of-the-art in magnetic resonance flow imaging studies is discussed previously [23], [24] and the framework can be applied to investigate cardiac blood motion as well.
However, our findings are supported by other studies, as discussed previously.
With the emergence of epigenetic biomarkers across multiple aspects of breast cancer research, this highlights a potential use for DNA methylation biomarkers as predictors of tamoxifen response with prospective application in neo-adjuvant studies, as discussed previously [ 13].
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