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The wide range of prevalence rates in these studies might be related to methodological differences between the studies, discrepancies in the application of criteria in different languages, differences in sociocultural backgrounds, and genetic factors.
Second, concordance between CNVs from differing aCGH experiments is low: in human studies discrepancies occur between analyses that assessed identical samples [2], [11], [12], [13]; in mouse studies there is low overlap between CNVs reported for the same inbred strains (37% between [14] and [5]).
Two investigators independently identified eligible studies; discrepancies were resolved by consensus with a third investigator.
For the quality assessment JvH & HvdH independently scored the included studies, discrepancies were examined by TVV after which consensus was reached.
During completion of the risk-of-bias assessment for the full set of studies, discrepancies between the reviewers are resolved by reaching agreement through discussion.
In most of these comparison studies, discrepancies found between the different assays were partly explained by the fact that these molecular assays were using different capture technologies for CTC isolation and very different detection systems.
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A number of studies report discrepancies in the values obtained from patients and the general population [ 5, 6].
Another criticism of the athlete-mortality literature is on methodological grounds; more specifically, cross-study discrepancies in the statistical tests and/or measures used.
In a survey article, Blau and Currie (2006) highlight the wide-ranging estimated elasticities of employment with respect to child care costs and attribute cross-study discrepancies largely to variation in biases from different estimation strategies.
In the current study this possible confound was investigated by studying discrepancies between alpha and mu power during the different phases of imitation learning.
Many experimental variables like cell type, MYC protein levels, length of time of aberrant MYC expression, etc. are likely to account for the study-to-study discrepancies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com